2003.08 - 2008.04　University of Pittsburgh　Ph.D


1999.09 - 2003.07　Beijing Normal University　B.S.

2018.10 - present　State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University　Professor


2018.01 - 2018.09　Institute of Biophysics　Professor


2011.10 - 2017.12　Institute of Biophysics　Associate Professor


2008.05 - 2011.09　University of Pittsburgh　Postdoc

Dr. Wu’s lab is interested in understanding cellular and molecular mechanisms regulating mammalian brain development and related diseases. There are three major topics in the laboratory: 1) Building up cell atlas of the developing mammalian neural system by multi-omics analyses; 2) Molecular property of neural progenitor cells and their function in human neural system development; 3) Understanding the molecular mechanisms of human neural system diseases.

1. Transcriptomic encoding of sensorimotor transformation in the midbrain. Xie Z, Wang M, Liu Z, Shang C, Zhang C,Sun L, Gu H, Ran G, Pei Q, Ma Q, Huang M, Zhang J, Lin R, Zhou Y, Zhang J, Zhao M, Luo M, Wu Q^#, Cao P^#, Wang X^#.Elife.2021 Jul 28;10:e69825. doi: 10.7554/eLife.69825. (^#Corresponding authors)

2. Shi Y, Wu Q, Wang X. Modeling brain development and diseases with human cerebral organoids. Curr Opin Neurobiol. 2021 Feb;66:103-115. doi: 10.1016/j.conb.2020.09.006. (Review)

3. Zhou X, Zhong S, Peng H, Liu J, Ding W, Sun L, Ma Q, Liu Z, Chen R, Wu Q, Wang X. Cellular and molecular properties of neural progenitors in the developing mammalian hypothalamus. Nat Communications.2020 Aug 13;11(1):4063. doi: 10.1038/s41467-020-17890-2.

4. Yi W, Lu Y, Zhong S, Zhang M^#, Sun L, Dong H, Wang M, Wei M, Xie H, Qu H, Peng R, Hong J, Yao Z, Tong Y, Wang W, Ma Q, Liu Z, Ma Y, Li S, Yin C, Liu J, Ma C, Wang X^#, Wu Q^#, Xue T^#. A single-cell transcriptome atlas of the aging human and macaque retina. National Science Review, 2020 August 25. nwaa179, doi.org/10.1093/nsr/nwaa179 (^#Corresponding authors)

5. Fan X, Fu Y, Zhou X, Sun L, Yang M, Wang M, Chen R, Wu Q, Yong J, Dong J, Wen L, Qiao J, Wang X, Tang F. Single-cell transcriptome analysis reveals cell lineage specification in temporal spatial patterns in human cortical development. Science Advances, 2020 Aug 21;6(34):eaaz2978. doi: 10.1126/sciadv.aaz2978

6. Ding W, Zhang C, Wang B, Zhou X, Sun L, Zhong S, Liu J, Zhang J, Wang X^#, Wu Q^#. Loss of the centrosomal protein Cenpj leads to dysfunction of the hypothalamus and obesity in mice. Sci China Life Sci. 2020 Aug 13. doi: 10.1007/s11427-020-1767-5. (^#Corresponding authors)

7. Sun L, Chen R, Li L, Yuan B, Song K, Pan N, Cheng T, Chang S, Lin K, He X, Wu Q, Xu F, Qiu Z, Wang X. Visualization and correction of social abnormalities-associated neural ensembles in adult MECP2 duplication mice. Science Bulletin. 2020 July 30; 65(14):1192-1202.

8. Liu J, Wang M, Sun L, Pan N, Zhang C, Zhang J, Zuo Z, He S, Wu Q^#, Wang X^#.  Integrative Analysis of in Vivo Recording with Single-Cell RNA-seq Data Reveals Molecular Properties of Light-Sensitive Neurons in Mouse V1. Protein Cell. 2020 Jun; 11(6): 417–432. (^#Corresponding authors)

9. Shi Y, Sun L, Wang M, Liu J, Zhong S, Li R, Li P, Guo L, Fang A, Chen R, Ge WP, Wu Q^#, Wang X^#. Vascularized human cortical organoids (vOrganoid) model cortical development in vivo Plos Biology. 2020; May 13;18(5). (^#Corresponding authors)

10. Lu Y, Shiau F, Yi W, Lu S, Wu Q, Pearson JD, Kallman A, Zhong S, Hoang T, Zuo Z, Zhao F, Zhang M, Tsai N, Zhuo Y, He S, Zhang J, Stein-O'Brien GL, Sherman TD, Duan X, Fertig EJ, Goff LA, Zack DJ, Handa JT, Xue T, Bremner R, Blackshaw S, Wang X, Clark BS. Single-cell analysis of human retina identifies evolutionarily conserved and species specific mechanisms controlling development. Developmental Cell. 2020; May 18;53(4):473-491.

11. Yin C, Zhou X, Yao Y, Wang W^#, Wu Q^#, Wang X^#. Abundant self-amplifying intermediate progenitors in the subventricular zone of the Chinese tree shrew neocortex. Cerebral Cortex. 2020 May 14;30(5):3370-3380.  (^#Corresponding authors)

12. Xie H, Zhang W, Zhang M, Akhtar T, Li Y, Yi W, Sun X, Zuo Z, Wei M, Fang X, Yao Z, Dong K, Zhong S, Liu Q, Shen Y, Wu Q, Wang X, Zhao H, Bao J,Qu K, Xue T. Chromatin accessibility analysis reveals regulatory dynamics of developing human retina and hiPSC-derived retinal organoids. Sci. Adv. 2020; 6 : eaay5247

13. Zhong S, Ding W, Sun L, Lu Y, Dong H, Fan X, Liu Z, Chen R, Zhang S, Ma Q, Tang F, Wu Q^#, Wang X^#. Decoding the development of the human hippocampus. Nature. 2020. Jan 577(7791): p. 531-536 (^#Corresponding authors)

14. Ding W*, Wu Q*, Sun L, Pan NC, Wang X. Cenpj regulates cilia disassembly and neurogenesis in the developing mouse cortex. Journal of Neuroscience. 2019 Mar 13;39(11):1994-2010. (*Equal contribution)

15. Pan NC, Fang A, Shen C, Sun L, Wu Q, Wang X. Early Excitatory Activity-dependent Maturation of Somatostatin Interneurons in Cortical Layer 2/3 of Mice. Cerebral Cortex. 2019 Sep 13;29(10):4107-4118.

16. Sun L^#, Chen R, Bai Y, Li J, Wu Q^#, Shen Q^#, Wang X^#. Morphological and Physiological Characteristics of Ebf2-EGFP-Expressing Cajal-Retzius Cells in Developing Mouse Neocortex. Cerebral Cortex, 2019 Sep. 29(9):3864–3878 (^#Corresponding authors)

17. Fan X, Dong J, Zhong S, Wei Y, Wu Q, Yan L, Yong J, Sun L, Wang X, Zhao Y, Wang W, Yan J, Wang X, Qiao J, Tang F. Spatial transcriptomic survey of human embryonic cerebral cortex by single-cell RNA-seq analysis. Cell Res. 2018 Jul;28(7):730-745.

18. Zhong S*, Zhang S*, Fan X*, Wu Q*, Yan L*, Dong J, Zhang H, Li L, Sun L, Pan N, Xu X, Tang F#, Zhang J#, Qiao J#, Wang X#. A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex. Nature. 2018 Mar 22;555(7697):524-528. （*Equal contribution）

19. Shi Y*, Li S*, Wu Q*, Sun L, Zhang J, Pan N, Wang Q, Bi Y, An J, Lu X, Gao GF, Wang X. Vertical Transmission of the Zika Virus Causes Neurological Disorders in Mouse Offspring. Sci Rep. 2018 Feb 23;8(1):3541. doi: 10.1038/s41598-018-21894-w. (*Equal contribution)

20. Liu J*, Liu W*, Yang L*, Wu Q*, Zhang H, Fang A, Li L, Xu X, Sun L, Zhang J, Tang F, Wang X. The Primate-Specific Gene TMEM14B Marks Outer Radial Glia Cells and Promotes Cortical Expansion and Folding, Cell Stem Cell. 2017 Nov 2;21(5):635-649.e8. doi: 10.1016/j.stem.2017.08.013. (*Equal contribution)

21. Li R, Sun L, Fang A, Li P, Wu Q^#, Wang X^#. Recapitulating cortical development with organoid culture in vitro and modeling abnormal spindle-like (ASPM related primary) microcephaly disease. Protein Cell. 2017 Nov;8(11):823-833. doi: 10.1007/s13238-017-0479-2. (^#Corresponding authors)

22. Wang Y*, Wu Q*, Yang P, Wang C, Liu J, Ding W, Liu W, Bai Y, Yang Y, Wang H, Gao S, Wang X. LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain. Nat Commun. 2016 Jan 22;7:10481. doi: 10.1038/ncomms10481. (*Equal contribution)

23. Kou Z*, Wu Q*, Kou X*, Yin C*, Wang H, Zuo Z, Zhuo Y, Chen A, Gao S, Wang X. CRISPR/Cas9-mediated genome engineering of the ferret. Cell Res. 2015 Dec;25(12):1372-5. doi: 10.1038/cr.2015.130. (*Equal contribution)

24. Wu Q, Dhir R, Wells A, Altered CXCR3 Isoform Expression Regulates Prostate Cancer Cell Migration and Invasion. Mol Cancer. 2012 Jan 11;11(1):3.

25. Wu Q, Sahasrabudhe RM, Luo LZ, Lewis DW, Gollin SM, Saunders WS. Deficiency in myosin light-chain phosphorylation causes cytokinesis failure and multipolarity in cancer cells. Oncogene. 2010 Jul 22;29(29):4183-93.