章晓辉老师课题组邀请了东北大学生命科学与健康学院特聘教授、李家驿教授到实验室做学术报告，欢迎感兴趣的老师和同学参加。

    以下为报告信息：

    题目：  致病蛋白的“朊蛋白样”传播 －帕金森病的发病新机制/Is Parkinson’s disease a prion disease? – Problems and Opportunities

    报告人：李家驿　博士、教授，东北大学生命科学与健康学院特聘教授

    时间：  3月10日（周二）上午10:00

    地点：  脑成像中心308会议室（大会议室）

    摘要: Parkinson’s disease (PD) is the most common movement disorder and the 2nd most common neurodegenerative diseases after Alzheimer’s disease. The hallmarks of the PD neuropathology are dopaminergic cell death in the substantia nigra of the midbrain (largely resulting in the motor symptoms) and protein (alpha-synuclein) aggregation. We recently showed evidence of alpha-synuclein cell-to-cell transfer using in vitro and in vivo models of PD. We also demonstrated that human alpha-synuclein and its aggregates can propagate from the intestine to the brain in long-distance after being administered in the gut by local protein injection or viral transduction. Live cell imaging indicates that both slow and fast components of axonal transport are involved in the trafficking of aggregated alpha -synuclein. These findings indicate that the prion-like property of alpha-synuclein is important for initiation and progression of PD pathology, thus, it holds promise as a new avenue for the development of future PD therapeutics.

    报告人简介：李家驿1982年在泸州医学院获学士学位，1988年在四川大学（华西医科大学）获硕士学位。1995年在瑞典哥德堡大学获得博士学位。自2011年任瑞典隆德大学(Lund University)瓦伦伯格神经科学中心教授。任东北大学生命科学与健康学院特聘教授。研究领域主要涉及神经退行性疾病帕金森病(Parkinson’s disease, PD)和亨廷顿病(Huntington’s disease, HD)的细胞和动物模型的病原性机理；以及干细胞治疗对神经退行性疾病的修复、移植策略和安全性评价。发表研究论文90余篇，论文被引用4700余次，h-index 34。